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BN40301R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse,Rat(predicted:Chicken,Cow) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40301R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse,Rat(predicted:Chicken,Cow) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
產(chǎn)品描述
| 英文名稱(chēng) | Nova1 |
| 中文名稱(chēng) | 神經(jīng)腫瘤Nova1抗原抗體 |
| 別 名 | Neuro oncological ventral antigen 1; Neuro-oncological ventral antigen 1; NOVA 1; Nova-1; Nova1; NOVA1_HUMAN; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; RNA binding protein Nova 1; RNA-binding protein Nova-1; Ventral neuron specific protein 1; Ventral neuron-specific protein 1. |
| 研究領(lǐng)域 | 腫瘤 細胞生物 神經(jīng)生物學(xué) 細胞類(lèi)型標志物 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Chicken, Cow, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nova1:411-510/510 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5). Function: May regulate RNA splicing or metabolism in a specific subset of developing neurons. Subunit: Interacts with PTBP2; the interaction is direct (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Brain. Similarity: Contains 3 KH domains. SWISS: P51513 Gene ID: 4857 Database links: Entrez Gene: 4857 Human Entrez Gene: 664883 Mouse Omim: 602157 Human SwissProt: Q2PFW9 Cynomolgus monkey SwissProt: P51513 Human SwissProt: Q9JKN6 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
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